Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
Publicly citable
Every problem has a stable citation code for reference and discussion.
Filtered by relevance
Search by category, geography, status, and keywords.
Builder-oriented
Use the repository to find startup ideas, policy leads, and research agendas.
4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Counterfeit medications sold through unauthorized online channels can be difficult to distinguish from legitimate products without lab testing, putting patients at serious risk. Scalable, affordable detection at the point of purchase remains an unresolved challenge.
health-biology
global-unspecified
affordable
counterfeit
patients
online
yet
build
reliable
technology
detect
pharmaceuticals
whether
philosophy-ethics
mathematics-logic
haven
technology-computing
determine
Dependency on imported medicines increases vulnerability to global supply shocks and raises prices. Regional pharma manufacturing hubs and harmonized regulatory standards could improve medicine security.
local-regional
africa
manufacturing
local
pharmaceutical
capacity
remains
limited
dependency
imported
medicines
global-unspecified
african
economics-resources
access
whether
supply
asia
open
Global / Unspecified, Global
Medicines used on Earth lose potency rapidly on orbit, endangering astronauts on long multi-year Mars missions. Developing radiation-shielded drug formulations and long-shelf-life stabilizing active compounds is required.
health-biology
global-unspecified
pharmaceuticals
break
down
significantly
faster
microgravity
cosmic
radiation
conditions
medicines
science-space
missions
support
medical
psychological
long
In major agricultural and industrial manufacturing regions across East and South Asia, overuse of antibiotics in livestock and unmonitored factory discharge have accelerated the proliferation of drug-resistant pathogens, threatening global healthcare systems.
health-biology
asia
india
agricultural
haven
halted
rapid
surge
antimicrobial
resistance
driven
unregulated
pharmaceutical
global-unspecified
systems
climate-environment
whether
philosophy-ethics
Poor supply chain oversight allows fake antibiotics, malaria medications, and life-saving drugs to enter rural retail markets, leading to treatment failures and drug resistance.
economics-resources
asia
myanmar
supply-chain
rural
haven
solved
crisis
counterfeit
substandard
pharmaceuticals
circulating
decentralized
pharmacies
global-unspecified
health-biology
african
philosophy-ethics
Foreign pharmaceutical companies patent compounds derived from traditional Asian herbal knowledge without benefit-sharing agreements with native communities.
society-governance
asia
india
traditional
haven
protected
indigenous
intellectual
property
rights
over
medicinal
plant
global-unspecified
climate-environment
african
philosophy-ethics
whether
open
Global / Unspecified, Global
Sophisticated fake prescriptions generated with AI assistance can be difficult for pharmacies to distinguish from legitimate ones without additional verification steps. Closing this gap remains an urgent unresolved challenge for pharmaceutical safety.
health-biology
global-unspecified
fake
prescriptions
yet
build
technology
reliably
detects
ai-generated
medical
illegally
whether
philosophy-ethics
mathematics-logic
technology-computing
way
prevent
open
Global / Unspecified, Global
Bacteria are evolving resistance faster than pharmaceutical companies are creating new antibiotics to fight them. Left unresolved, common infections could become deadly again within a few decades.
health-biology
global-unspecified
bacteria
faster
new
antibiotics
stop
antibiotic-resistant
spreading
develop
evolving
resistance
philosophy-ethics
whether
haven
determine
prevent
mathematics-logic
Build transparent testing, traceability, and regulatory methods for identifying heavy metals, steroids, pharmaceuticals, and contaminants in traditional medicine supply chains.
economics-resources
asia
china
supply-chain
traditional
detecting
toxic
adulterants
herbal
medicines
build
transparent
testing
traceability
supply
society-governance
methods
chains
Despite recognition of its importance, reliable methods for biotechnologies enabling the production of pharmaceuticals and fine chemicals from renewable feedstocks are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
europe
poland
biotechnologies
enabling
production
pharmaceuticals
fine
chemicals
renewable
feedstocks
deployable
technologies
methods
systems
society-governance
barriers
high