World Solve

Addressing stigma around disease continuing is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.

The problem of growing seasons changing continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.

coastal cities threatened by rising seas remains one of the most urgent challenges of our time. Systems currently in place are inadequate for the scale and complexity of the problem. A successful approach must work where resources are scarcest and demonstrate clear, measurable results. It should identify possible harms, respect local agency, and show how the solution can be maintained and expanded by the communities it is meant to serve.

Future progress on human development and planetary health depends on solving high burden of heart disease. Conventional approaches have proven insufficient. The required intervention must integrate community knowledge, data and appropriate technology while remaining affordable, privacy-preserving and operable with minimal external support. Strong solutions will articulate measurable impact metrics, risk mitigation strategies, and a plan for sustained operation by local actors after the pilot phase.

emergence of new infectious diseases remains one of the most urgent challenges of our time. Systems currently in place are inadequate for the scale and complexity of the problem. A successful approach must work where resources are scarcest and demonstrate clear, measurable results. It should identify possible harms, respect local agency, and show how the solution can be maintained and expanded by the communities it is meant to serve.

The problem of insects expanding their range and spreading disease continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.

The problem of overfishing emptying the seas continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.

rapid spread of plant diseases remains one of the most urgent challenges of our time. Systems currently in place are inadequate for the scale and complexity of the problem. A successful approach must work where resources are scarcest and demonstrate clear, measurable results. It should identify possible harms, respect local agency, and show how the solution can be maintained and expanded by the communities it is meant to serve.

The problem of open defecation continuing to spread disease continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.

The problem of household cooking with wood and charcoal causing lung disease continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.

Addressing widespread diseases caused by contaminated water is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.

Many agricultural and infrastructure systems are designed around historical seasons that may no longer exist. A useful solution must help governments revise calendars, reservoirs, insurance, crops, and public budgets under deep uncertainty. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.

Ageing populations, urban diets, and pollution will drive surges in cardiovascular disease, diabetes, cancer, and chronic respiratory conditions. Scalable chronic-care models, digital coaching tools, and preventive policy reforms are needed.

By the 2030s and 2040s, extreme heat and shifting mosquito ranges will expand malaria, dengue, and other infections into new regions. Heat-health early-warning systems and climate-sensitive disease-modelling platforms must be deployed.

Genomic and biomarker-driven therapies will transform oncology and rare disease care, but high costs and limited capacity risk concentrating benefits in wealthy populations. Fair pricing, global data-sharing, and low-cost diagnostics will be critical.

Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.

Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

Lyme disease, dengue, and other infections may reach new regions. Integrated vector-surveillance and control platforms will be crucial.