What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We don't have an effective way to treat chronic digestive bloating that doesn't respond to standard dietary changes.
open
Global / Unspecified, Global
Some patients experience persistent bloating despite trying common dietary interventions, suggesting other underlying digestive issues that current medicine doesn't fully address. A more targeted treatment approach remains needed.
Citation ID: WS00646
Title: We don't have an effective way to treat chronic digestive bloating that doesn't respond to standard dietary changes.
URL: https://www.worldsolve.org/index.php?api=problem&id=646
We haven't found a way to prevent the recurrence of anxiety disorders after successful initial treatment.
open
Global / Unspecified, Global
Many patients successfully treated for anxiety disorders experience recurrence years later, and current treatment approaches don't reliably prevent this from happening. A more effective long-term relapse prevention strategy remains needed.
Citation ID: WS00645
Title: We haven't found a way to prevent the recurrence of anxiety disorders after successful initial treatment.
URL: https://www.worldsolve.org/index.php?api=problem&id=645
We can't yet fully explain why some children develop severe complications from chickenpox while most recover easily.
open
Global / Unspecified, Global
Most children recover from chickenpox without serious issues, but a small number develop severe complications, and predicting who is at higher risk remains imprecise. Better prediction could help target preventive care more effectively.
Citation ID: WS00644
Title: We can't yet fully explain why some children develop severe complications from chickenpox while most recover easily.
URL: https://www.worldsolve.org/index.php?api=problem&id=644
We don't have an effective, scalable way to treat chronic ear ringing caused by long-term noise exposure in workers.
open
Global / Unspecified, Global
Workers in noisy industries often develop chronic tinnitus that current treatment options manage rather than resolve, and workplace prevention measures remain inconsistently enforced globally. Both better treatment and prevention remain needed.
Citation ID: WS00643
Title: We don't have an effective, scalable way to treat chronic ear ringing caused by long-term noise exposure in workers.
URL: https://www.worldsolve.org/index.php?api=problem&id=643
We haven't solved how to detect early liver damage caused by long-term medication use before it becomes severe.
open
Global / Unspecified, Global
Some medications carry a risk of gradual liver damage that often goes undetected until routine screening or symptoms reveal significant harm has already occurred. More sensitive, earlier detection methods remain an unmet need.
Citation ID: WS00642
Title: We haven't solved how to detect early liver damage caused by long-term medication use before it becomes severe.
URL: https://www.worldsolve.org/index.php?api=problem&id=642
We can't yet fully prevent the recurrence of kidney infections in patients prone to developing them repeatedly.
open
Global / Unspecified, Global
Some patients experience recurring kidney infections despite standard preventive antibiotics, suggesting underlying anatomical or immune factors that current treatment doesn't fully address. A more effective long-term prevention method remains needed.
Citation ID: WS00641
Title: We can't yet fully prevent the recurrence of kidney infections in patients prone to developing them repeatedly.
URL: https://www.worldsolve.org/index.php?api=problem&id=641
We don't have an effective way to treat chronic fatigue caused by iron deficiency that persists despite supplementation.
open
Global / Unspecified, Global
Some patients with iron deficiency continue experiencing fatigue even after supplementation corrects their iron levels, suggesting other contributing factors that aren't fully understood. A more complete treatment approach remains needed.
Citation ID: WS00640
Title: We don't have an effective way to treat chronic fatigue caused by iron deficiency that persists despite supplementation.
URL: https://www.worldsolve.org/index.php?api=problem&id=640
We haven't found a reliable way to prevent the recurrence of migraines triggered by weather changes.
open
Global / Unspecified, Global
Some migraine sufferers report weather-related triggers that current preventive medications don't reliably address. A more targeted prevention approach for this specific trigger remains undeveloped.
Citation ID: WS00639
Title: We haven't found a reliable way to prevent the recurrence of migraines triggered by weather changes.
URL: https://www.worldsolve.org/index.php?api=problem&id=639
We can't yet fully explain why some people develop chronic complications from typhoid despite treatment.
open
Global / Unspecified, Global
A subset of typhoid patients continue experiencing health issues after apparently successful treatment, and understanding why this occurs in some but not others remains incomplete. Better long-term follow-up care remains needed.
Citation ID: WS00638
Title: We can't yet fully explain why some people develop chronic complications from typhoid despite treatment.
URL: https://www.worldsolve.org/index.php?api=problem&id=638
We don't have an effective, widely available way to treat chronic hoarseness caused by vocal cord issues.
open
Global / Unspecified, Global
Persistent hoarseness linked to vocal cord problems can be difficult to fully resolve, especially for people who rely heavily on their voice for work. A more effective, accessible treatment approach remains needed.
Citation ID: WS00637
Title: We don't have an effective, widely available way to treat chronic hoarseness caused by vocal cord issues.
URL: https://www.worldsolve.org/index.php?api=problem&id=637
We haven't solved how to detect and treat gestational hypertension early enough to prevent complications.
open
Global / Unspecified, Global
Elevated blood pressure during pregnancy can develop into more serious complications if not caught and managed early, and screening consistency varies across different healthcare settings. Improving early, consistent detection remains an unmet global need.
Citation ID: WS00636
Title: We haven't solved how to detect and treat gestational hypertension early enough to prevent complications.
URL: https://www.worldsolve.org/index.php?api=problem&id=636
We can't yet fully prevent the joint pain and fatigue that sometimes follow dengue fever recovery.
open
Global / Unspecified, Global
Some dengue survivors experience lingering joint pain and fatigue for weeks or months after the acute infection has cleared. Better treatment for this post-infection recovery period remains underdeveloped.
Citation ID: WS00635
Title: We can't yet fully prevent the joint pain and fatigue that sometimes follow dengue fever recovery.
URL: https://www.worldsolve.org/index.php?api=problem&id=635
We don't have an effective way to treat chronic nasal congestion that doesn't respond to standard allergy or sinus treatment.
open
Global / Unspecified, Global
Some patients experience persistent nasal congestion despite trying multiple standard treatments, suggesting other underlying causes that current medicine doesn't fully address. A more targeted treatment approach remains needed.
Citation ID: WS00634
Title: We don't have an effective way to treat chronic nasal congestion that doesn't respond to standard allergy or sinus treatment.
URL: https://www.worldsolve.org/index.php?api=problem&id=634
We haven't found a way to prevent the recurrence of bacterial pneumonia in patients with chronic lung disease.
open
Global / Unspecified, Global
Patients with chronic lung conditions remain at ongoing risk of repeated bacterial pneumonia infections despite vaccination and preventive care. A more effective, targeted prevention approach remains needed for this vulnerable group.
Citation ID: WS00633
Title: We haven't found a way to prevent the recurrence of bacterial pneumonia in patients with chronic lung disease.
URL: https://www.worldsolve.org/index.php?api=problem&id=633
We can't yet fully explain why some patients experience chronic pain after nerve-related surgeries meant to relieve it.
open
Global / Unspecified, Global
Surgeries designed to relieve nerve-related pain occasionally result in new or persistent pain instead, and predicting which patients are at risk remains imprecise. Better prediction and prevention could improve surgical outcomes for chronic pain patients.
Citation ID: WS00632
Title: We can't yet fully explain why some patients experience chronic pain after nerve-related surgeries meant to relieve it.
URL: https://www.worldsolve.org/index.php?api=problem&id=632
We don't have an effective, scalable way to treat chronic wounds in patients with poor circulation.
open
Global / Unspecified, Global
Chronic wounds, especially in diabetic patients with poor circulation, can take months to heal or never fully heal, increasing risk of serious infection. A more effective, widely accessible treatment approach remains needed.
Citation ID: WS00631
Title: We don't have an effective, scalable way to treat chronic wounds in patients with poor circulation.
URL: https://www.worldsolve.org/index.php?api=problem&id=631
We haven't solved how to detect celiac disease earlier in patients whose symptoms are mild or atypical.
open
Global / Unspecified, Global
Celiac disease can present with subtle or unusual symptoms that delay diagnosis for years in some patients, allowing ongoing intestinal damage to occur. Better, more accessible screening for atypical cases remains an unmet need.
Citation ID: WS00630
Title: We haven't solved how to detect celiac disease earlier in patients whose symptoms are mild or atypical.
URL: https://www.worldsolve.org/index.php?api=problem&id=630
We can't yet fully prevent the recurrence of ovarian cysts in women prone to developing them repeatedly.
open
Global / Unspecified, Global
Some women experience recurring ovarian cysts despite treatment, and prevention options remain limited mostly to hormonal management rather than addressing the underlying cause. A more effective prevention approach remains needed.
Citation ID: WS00629
Title: We can't yet fully prevent the recurrence of ovarian cysts in women prone to developing them repeatedly.
URL: https://www.worldsolve.org/index.php?api=problem&id=629
We don't have an effective way to treat chronic restless leg syndrome for a significant share of patients.
open
Global / Unspecified, Global
Restless leg syndrome can disrupt sleep and daily life for years, and current medications don't provide adequate relief for every patient who has it. A more universally effective treatment remains undeveloped.
Citation ID: WS00628
Title: We don't have an effective way to treat chronic restless leg syndrome for a significant share of patients.
URL: https://www.worldsolve.org/index.php?api=problem&id=628
We haven't found a reliable way to prevent hearing loss caused by frequent ear infections in early childhood.
open
Global / Unspecified, Global
Repeated ear infections in young children can sometimes lead to lasting hearing problems if not caught and treated quickly enough. More consistent early detection and treatment access remain incomplete, particularly in underserved areas.
Citation ID: WS00627
Title: We haven't found a reliable way to prevent hearing loss caused by frequent ear infections in early childhood.
URL: https://www.worldsolve.org/index.php?api=problem&id=627
