What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We haven't found a way to make organ donation opt-out, not opt-in, fairly and globally.
open
Global / Unspecified, Global
Countries with opt-out organ donation systems tend to have far higher donation rates, saving more lives, but implementing this fairly and ethically worldwide remains politically and culturally difficult.
Citation ID: WS00226
Title: We haven't found a way to make organ donation opt-out, not opt-in, fairly and globally.
URL: https://www.worldsolve.org/index.php?api=problem&id=226
We can't yet explain why identical treatments work well for some patients and not others with the same disease.
open
Global / Unspecified, Global
Personalized medicine is improving, but doctors still can't always predict in advance which patients will respond to a given treatment. Solving this could avoid painful trial-and-error treatment periods for patients.
Citation ID: WS00225
Title: We can't yet explain why identical treatments work well for some patients and not others with the same disease.
URL: https://www.worldsolve.org/index.php?api=problem&id=225
We don't have a widely available treatment that slows the progression of most forms of dementia.
open
Global / Unspecified, Global
Existing dementia treatments offer only modest, temporary relief from symptoms rather than meaningfully slowing the underlying disease. A real disease-modifying treatment remains one of medicine's most sought-after breakthroughs.
Citation ID: WS00224
Title: We don't have a widely available treatment that slows the progression of most forms of dementia.
URL: https://www.worldsolve.org/index.php?api=problem&id=224
We haven't solved how to detect sepsis early enough to prevent it from becoming fatal.
open
Global / Unspecified, Global
Sepsis can escalate from a treatable infection to a life-threatening emergency within hours, and current diagnosis often catches it too late. Faster detection tools could dramatically reduce sepsis deaths in hospitals.
Citation ID: WS00223
Title: We haven't solved how to detect sepsis early enough to prevent it from becoming fatal.
URL: https://www.worldsolve.org/index.php?api=problem&id=223
We can't yet reverse hearing loss caused by aging or long-term noise exposure.
open
Global / Unspecified, Global
Once the tiny hair cells in the inner ear are damaged, human bodies can't naturally regrow them, making most hearing loss permanent. Cell regeneration therapies show early promise but remain far from mainstream treatment.
Citation ID: WS00222
Title: We can't yet reverse hearing loss caused by aging or long-term noise exposure.
URL: https://www.worldsolve.org/index.php?api=problem&id=222
We don't have affordable genetic testing available to everyone who could benefit from it.
open
Global / Unspecified, Global
Genetic testing can reveal risk for serious inherited conditions, but cost and access limit it mostly to wealthier patients and countries. Broader affordability could catch preventable conditions far earlier for many more people.
Citation ID: WS00221
Title: We don't have affordable genetic testing available to everyone who could benefit from it.
URL: https://www.worldsolve.org/index.php?api=problem&id=221
We haven't found a way to stop the immune system from attacking healthy joints in arthritis.
open
Global / Unspecified, Global
Autoimmune arthritis causes the body's own immune system to damage joint tissue, leading to chronic pain and disability. Current treatments manage inflammation but don't address why the immune system attacks in the first place.
Citation ID: WS00220
Title: We haven't found a way to stop the immune system from attacking healthy joints in arthritis.
URL: https://www.worldsolve.org/index.php?api=problem&id=220
We can't yet grow blood in a lab reliably enough to end donor blood shortages.
open
Global / Unspecified, Global
Blood donation shortages remain a recurring problem worldwide, especially during emergencies when demand spikes suddenly. Lab-grown blood could remove dependence on donor supply entirely, but the technology isn't yet practical at scale.
Citation ID: WS00219
Title: We can't yet grow blood in a lab reliably enough to end donor blood shortages.
URL: https://www.worldsolve.org/index.php?api=problem&id=219
We don't have a reliable cure for tinnitus, the constant ringing some people hear in their ears.
open
Global / Unspecified, Global
Tinnitus affects a significant portion of the population and can seriously impact quality of life, yet current treatments only manage symptoms rather than eliminate the underlying cause.
Citation ID: WS00218
Title: We don't have a reliable cure for tinnitus, the constant ringing some people hear in their ears.
URL: https://www.worldsolve.org/index.php?api=problem&id=218
We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else.
open
Global / Unspecified, Global
A small number of people show natural resistance to certain infections or conditions, and understanding why could reveal entirely new treatment approaches. This resistance remains only partially understood at a genetic level.
Citation ID: WS00217
Title: We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else.
URL: https://www.worldsolve.org/index.php?api=problem&id=217
We can't yet regenerate damaged heart tissue after a heart attack.
open
Global / Unspecified, Global
Heart muscle doesn't regenerate well once damaged, often leaving survivors with permanently reduced heart function. Finding a way to regrow healthy heart tissue could transform recovery for millions of survivors.
Citation ID: WS00216
Title: We can't yet regenerate damaged heart tissue after a heart attack.
URL: https://www.worldsolve.org/index.php?api=problem&id=216
We don't have an effective vaccine for most types of cancer.
open
Global / Unspecified, Global
Unlike infectious diseases, cancer arises from a person's own cells mutating, making a universal vaccine far more complex to design. Progress exists for a few cancer types, but a broadly effective approach remains unsolved.
Citation ID: WS00215
Title: We don't have an effective vaccine for most types of cancer.
URL: https://www.worldsolve.org/index.php?api=problem&id=215
We haven't solved how to prevent light pollution from disrupting nocturnal wildlife in growing cities.
open
Global / Unspecified, Global
Artificial lighting confuses migration patterns, hunting behavior, and reproduction cycles in many nocturnal species, yet city lighting keeps expanding with growth. A widely adopted, wildlife-friendly lighting standard remains missing.
Citation ID: WS00214
Title: We haven't solved how to prevent light pollution from disrupting nocturnal wildlife in growing cities.
URL: https://www.worldsolve.org/index.php?api=problem&id=214
We can't yet make air conditioning widely available in poorer, hot regions without worsening emissions.
open
Global / Unspecified, Global
Cooling saves lives during extreme heat, but most air conditioners rely on energy sources and refrigerants that contribute to climate change. A low-emission cooling solution accessible to poorer regions remains urgently needed.
Citation ID: WS00213
Title: We can't yet make air conditioning widely available in poorer, hot regions without worsening emissions.
URL: https://www.worldsolve.org/index.php?api=problem&id=213
We don't have a fair way to manage water rights between countries that share the same river.
open
Global / Unspecified, Global
Rivers often flow through multiple countries, and disputes over how much water each country can use remain a persistent source of tension. A widely accepted, fair sharing framework remains unbuilt in many major river basins.
Citation ID: WS00212
Title: We don't have a fair way to manage water rights between countries that share the same river.
URL: https://www.worldsolve.org/index.php?api=problem&id=212
We haven't found an affordable way to retrofit old buildings to be energy efficient.
open
Global / Unspecified, Global
Older buildings often waste huge amounts of energy through poor insulation and outdated systems, but retrofitting them is usually expensive and disruptive. Cheaper retrofit solutions could unlock major emissions reductions from existing infrastructure.
Citation ID: WS00211
Title: We haven't found an affordable way to retrofit old buildings to be energy efficient.
URL: https://www.worldsolve.org/index.php?api=problem&id=211
We can't yet stop soil erosion from steadily reducing farmland productivity worldwide.
open
Global / Unspecified, Global
Poor farming practices and deforestation are wearing away fertile topsoil faster than nature can rebuild it, threatening long-term food production. A scalable solution to reverse this trend remains unresolved globally.
Citation ID: WS00210
Title: We can't yet stop soil erosion from steadily reducing farmland productivity worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=210
We don't have a reliable, affordable way to detect toxic algae blooms in water supplies before they become dangerous.
open
Global / Unspecified, Global
Algae blooms can quickly poison drinking water sources, sometimes going undetected until people or animals get sick. Faster, cheaper detection methods could prevent this from becoming a public health crisis.
Citation ID: WS00209
Title: We don't have a reliable, affordable way to detect toxic algae blooms in water supplies before they become dangerous.
URL: https://www.worldsolve.org/index.php?api=problem&id=209
We haven't solved how to make electric vehicle batteries fully recyclable at the end of their life.
open
Global / Unspecified, Global
As electric vehicles become more common, so will the used batteries, most of which still lack an efficient, complete recycling process. Solving this prevents a looming new wave of battery waste.
Citation ID: WS00208
Title: We haven't solved how to make electric vehicle batteries fully recyclable at the end of their life.
URL: https://www.worldsolve.org/index.php?api=problem&id=208
We can't yet stop illegal fishing from depleting fish stocks faster than regulations can respond.
open
Global / Unspecified, Global
Fishing fleets can evade detection in vast, poorly monitored ocean areas, undermining conservation efforts meant to protect fish populations. Better real-time monitoring at sea remains a critical unsolved gap.
Citation ID: WS00207
Title: We can't yet stop illegal fishing from depleting fish stocks faster than regulations can respond.
URL: https://www.worldsolve.org/index.php?api=problem&id=207
