What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We can't yet reverse the biological damage caused by long-term stress.
open
Global / Unspecified, Global
Chronic stress physically changes the brain and body over time, and we don't yet have treatments that fully reverse that damage. Understanding this could transform how we treat burnout, trauma, and related illness.
Citation ID: WS00075
Title: We can't yet reverse the biological damage caused by long-term stress.
URL: https://www.worldsolve.org/index.php?api=problem&id=75
We don't have a scalable way to detect rare genetic diseases in newborns everywhere.
open
Global / Unspecified, Global
Wealthier countries can screen for many rare genetic conditions at birth, but most of the world's newborns are never tested. Expanding this access could catch treatable conditions before irreversible damage occurs.
Citation ID: WS00074
Title: We don't have a scalable way to detect rare genetic diseases in newborns everywhere.
URL: https://www.worldsolve.org/index.php?api=problem&id=74
We haven't found a way to make mental health care as accessible as physical health care.
open
Global / Unspecified, Global
Getting a broken bone fixed is usually straightforward; getting consistent mental health support often isn't, due to cost, stigma, and shortage of providers. Closing this gap could prevent enormous, often invisible suffering.
Citation ID: WS00073
Title: We haven't found a way to make mental health care as accessible as physical health care.
URL: https://www.worldsolve.org/index.php?api=problem&id=73
We can't stop the rise of childhood obesity and related diseases worldwide.
open
Global / Unspecified, Global
Kids today are developing weight-related health problems that used to appear mostly in adults, and this trend is accelerating globally. Solving it needs more than individual willpower, it needs changes to food systems and environments.
Citation ID: WS00072
Title: We can't stop the rise of childhood obesity and related diseases worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=72
We don't have a cure for most forms of paralysis caused by spinal injury.
open
Global / Unspecified, Global
Once the spinal cord is severely damaged, current medicine offers little hope of restoring movement. Advances in nerve regeneration and brain-computer interfaces are promising but not yet a real cure.
Citation ID: WS00071
Title: We don't have a cure for most forms of paralysis caused by spinal injury.
URL: https://www.worldsolve.org/index.php?api=problem&id=71
We haven't solved the shortage of donor organs for transplants.
open
Global / Unspecified, Global
Thousands of people die every year waiting for organs that never become available. Lab-grown organs or better donation systems could close this life-threatening gap.
Citation ID: WS00070
Title: We haven't solved the shortage of donor organs for transplants.
URL: https://www.worldsolve.org/index.php?api=problem&id=70
We can't fully explain why obesity is so hard to treat long-term for most people.
open
Global / Unspecified, Global
Diet and exercise advice hasn't solved the obesity epidemic, and the biological reasons weight loss is so hard to sustain remain only partly understood. A deeper understanding could lead to treatments that actually last.
Citation ID: WS00069
Title: We can't fully explain why obesity is so hard to treat long-term for most people.
URL: https://www.worldsolve.org/index.php?api=problem&id=69
We don't have a cheap, at-home test that can screen for most major diseases at once.
open
Global / Unspecified, Global
Detecting serious illness usually still requires multiple separate tests, doctor visits, and significant cost, which many people simply skip. A single affordable screening test could catch problems that currently go unnoticed for years.
Citation ID: WS00068
Title: We don't have a cheap, at-home test that can screen for most major diseases at once.
URL: https://www.worldsolve.org/index.php?api=problem&id=68
We haven't found a reliable way to predict who will develop mental illness before it starts.
open
Global / Unspecified, Global
Depression, anxiety, and other mental health conditions often go undetected until symptoms are already severe. Earlier, more reliable prediction could allow prevention instead of just treatment after the fact.
Citation ID: WS00067
Title: We haven't found a reliable way to predict who will develop mental illness before it starts.
URL: https://www.worldsolve.org/index.php?api=problem&id=67
We can't reverse blindness or deafness caused by nerve damage in most cases.
open
Global / Unspecified, Global
Once the optic or auditory nerves are damaged beyond a certain point, current medicine can't restore lost sight or hearing. Emerging nerve regeneration research is promising but still far from practical treatment.
Citation ID: WS00066
Title: We can't reverse blindness or deafness caused by nerve damage in most cases.
URL: https://www.worldsolve.org/index.php?api=problem&id=66
We don't fully understand why some people age much slower than others.
open
Global / Unspecified, Global
Some people reach old age with sharp minds and healthy bodies, while others decline much earlier, and genetics only explains part of it. Understanding this gap could extend healthy years of life for far more people.
Citation ID: WS00065
Title: We don't fully understand why some people age much slower than others.
URL: https://www.worldsolve.org/index.php?api=problem&id=65
We haven't solved chronic pain well enough to treat it without risking addiction.
open
Global / Unspecified, Global
Millions of people with chronic pain are stuck choosing between inadequate relief or medications that carry serious addiction risk. A safer, equally effective alternative remains one of medicine's most requested breakthroughs.
Citation ID: WS00064
Title: We haven't solved chronic pain well enough to treat it without risking addiction.
URL: https://www.worldsolve.org/index.php?api=problem&id=64
We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
open
Global / Unspecified, Global
Bacteria are evolving resistance faster than pharmaceutical companies are creating new antibiotics to fight them. Left unresolved, common infections could become deadly again within a few decades.
Citation ID: WS00063
Title: We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
URL: https://www.worldsolve.org/index.php?api=problem&id=63
We don't have affordable cancer screening that catches every type early enough to treat well.
open
Global / Unspecified, Global
Some cancers are caught early and treated successfully, while others are found too late simply because no cheap, accurate screening exists for them. Broader early detection could save far more lives than treatment breakthroughs alone.
Citation ID: WS00062
Title: We don't have affordable cancer screening that catches every type early enough to treat well.
URL: https://www.worldsolve.org/index.php?api=problem&id=62
We haven't found a cure for the common cold despite decades of trying.
open
Global / Unspecified, Global
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
Citation ID: WS00061
Title: We haven't found a cure for the common cold despite decades of trying.
URL: https://www.worldsolve.org/index.php?api=problem&id=61
We can't grow replacement organs that a patient's body won't reject.
open
Global / Unspecified, Global
Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.
Citation ID: WS00060
Title: We can't grow replacement organs that a patient's body won't reject.
URL: https://www.worldsolve.org/index.php?api=problem&id=60
We don't have a universal vaccine that protects against all strains of the flu.
open
Global / Unspecified, Global
The flu virus mutates constantly, forcing a new vaccine guess every year that sometimes misses the mark. A universal flu vaccine could end this annual guessing game and prevent thousands of deaths.
Citation ID: WS00059
Title: We don't have a universal vaccine that protects against all strains of the flu.
URL: https://www.worldsolve.org/index.php?api=problem&id=59
We can't cure most autoimmune diseases, only manage their symptoms.
open
Global / Unspecified, Global
Conditions like lupus, rheumatoid arthritis, and multiple sclerosis occur when the body attacks itself, and current treatments mostly suppress symptoms rather than fix the root cause. Millions live with lifelong management instead of a real cure.
Citation ID: WS00058
Title: We can't cure most autoimmune diseases, only manage their symptoms.
URL: https://www.worldsolve.org/index.php?api=problem&id=58
We don't have enough clean water infrastructure to serve growing cities in dry regions.
open
Global / Unspecified, Global
Many fast-growing cities in arid regions are outpacing the water systems built to serve them, leading to shortages and rationing. Solving this needs both new infrastructure and smarter long-term water planning.
Citation ID: WS00057
Title: We don't have enough clean water infrastructure to serve growing cities in dry regions.
URL: https://www.worldsolve.org/index.php?api=problem&id=57
We haven't solved how to make air travel low-carbon without making it unaffordable.
open
Global / Unspecified, Global
Sustainable aviation fuel and electric planes exist in early forms but remain far more expensive than traditional jet fuel. Making clean flying both effective and affordable is still an open engineering and economic problem.
Citation ID: WS00056
Title: We haven't solved how to make air travel low-carbon without making it unaffordable.
URL: https://www.worldsolve.org/index.php?api=problem&id=56
