What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We can't yet fully treat chronic constipation that doesn't respond to standard dietary and medical interventions.
open
Global / Unspecified, Global
A subset of patients with chronic constipation don't find relief through typical dietary changes or over-the-counter treatments, leaving them with persistent discomfort and few further options. More effective alternatives remain limited.
Citation ID: WS00566
Title: We can't yet fully treat chronic constipation that doesn't respond to standard dietary and medical interventions.
URL: https://www.worldsolve.org/index.php?api=problem&id=566
We don't have an effective way to prevent hearing loss associated with normal aging.
open
Global / Unspecified, Global
Age-related hearing loss affects a large share of older adults, and current treatment focuses on hearing aids rather than preventing or reversing the underlying decline. A true preventive treatment remains undeveloped.
Citation ID: WS00565
Title: We don't have an effective way to prevent hearing loss associated with normal aging.
URL: https://www.worldsolve.org/index.php?api=problem&id=565
We haven't solved how to detect early signs of heart disease in people with no obvious risk factors.
open
Global / Unspecified, Global
Some people who die of sudden cardiac events had no known risk factors or warning signs beforehand, suggesting current screening methods miss a meaningful share of at-risk individuals. Better detection tools for this group remain an open need.
Citation ID: WS00564
Title: We haven't solved how to detect early signs of heart disease in people with no obvious risk factors.
URL: https://www.worldsolve.org/index.php?api=problem&id=564
We can't yet fully explain why chronic itching sometimes occurs without any visible skin condition.
open
Global / Unspecified, Global
Some patients experience persistent, unexplained itching with no identifiable skin problem, kidney issue, or other clear cause, making treatment largely trial and error. Understanding the underlying mechanism remains incomplete.
Citation ID: WS00563
Title: We can't yet fully explain why chronic itching sometimes occurs without any visible skin condition.
URL: https://www.worldsolve.org/index.php?api=problem&id=563
We don't have a reliable way to prevent the recurrence of gestational diabetes in future pregnancies.
open
Global / Unspecified, Global
Women who develop gestational diabetes in one pregnancy are at higher risk in future pregnancies, and current prevention strategies only partially reduce this risk. A more effective prevention method remains needed.
Citation ID: WS00562
Title: We don't have a reliable way to prevent the recurrence of gestational diabetes in future pregnancies.
URL: https://www.worldsolve.org/index.php?api=problem&id=562
We haven't found an effective way to treat chronic fatigue in cancer survivors after treatment ends.
open
Global / Unspecified, Global
Many people who survive cancer continue experiencing significant fatigue for months or years after treatment concludes, and effective, targeted treatment for this remains limited. Addressing survivorship symptoms like this remains an underfunded area of care.
Citation ID: WS00561
Title: We haven't found an effective way to treat chronic fatigue in cancer survivors after treatment ends.
URL: https://www.worldsolve.org/index.php?api=problem&id=561
We can't yet fully prevent the chronic pain that sometimes follows shingles infections.
open
Global / Unspecified, Global
A portion of shingles patients develop long-term nerve pain, known as postherpetic neuralgia, that persists long after the rash has healed. Preventing this complication before it develops remains an incomplete area of treatment.
Citation ID: WS00560
Title: We can't yet fully prevent the chronic pain that sometimes follows shingles infections.
URL: https://www.worldsolve.org/index.php?api=problem&id=560
We don't have a widely available way to screen for prostate cancer that avoids both under- and over-diagnosis.
open
Global / Unspecified, Global
Current prostate cancer screening can miss dangerous cancers or flag ones that would never have caused harm, leading to unnecessary treatment in some cases and missed cancers in others. A more precise screening method remains an unmet need.
Citation ID: WS00559
Title: We don't have a widely available way to screen for prostate cancer that avoids both under- and over-diagnosis.
URL: https://www.worldsolve.org/index.php?api=problem&id=559
We haven't solved how to prevent surgical site infections in resource-limited hospital settings.
open
Global / Unspecified, Global
Hospitals with limited resources for sterile equipment and infection control see higher rates of post-surgical infections than better-equipped facilities. Closing this gap requires both medical and infrastructure solutions that remain incomplete in many regions.
Citation ID: WS00558
Title: We haven't solved how to prevent surgical site infections in resource-limited hospital settings.
URL: https://www.worldsolve.org/index.php?api=problem&id=558
We can't yet fully explain why some autoimmune conditions go into remission on their own while others don't.
open
Global / Unspecified, Global
Some patients with autoimmune diseases experience unexplained periods of remission without clear treatment causes, while others never do. Understanding this could reveal new treatment pathways currently hidden within the body's own natural mechanisms.
Citation ID: WS00557
Title: We can't yet fully explain why some autoimmune conditions go into remission on their own while others don't.
URL: https://www.worldsolve.org/index.php?api=problem&id=557
We don't have an effective way to fully prevent the recurrence of depression triggered by seasonal changes.
open
Global / Unspecified, Global
Seasonal affective disorder returns predictably each year for many patients, and current treatments manage symptoms during episodes rather than preventing them from recurring altogether. A more preventive approach remains undeveloped.
Citation ID: WS00556
Title: We don't have an effective way to fully prevent the recurrence of depression triggered by seasonal changes.
URL: https://www.worldsolve.org/index.php?api=problem&id=556
We haven't found a reliable way to detect early-stage bladder cancer using a simple urine test.
open
Global / Unspecified, Global
Bladder cancer often requires invasive procedures for definitive diagnosis, and current urine-based screening tools aren't yet reliable enough to serve as a widespread early detection method. A better non-invasive test remains an open need.
Citation ID: WS00555
Title: We haven't found a reliable way to detect early-stage bladder cancer using a simple urine test.
URL: https://www.worldsolve.org/index.php?api=problem&id=555
We can't yet fully prevent the bone density loss that occurs after menopause.
open
Global / Unspecified, Global
Hormonal changes after menopause accelerate bone loss, increasing fracture risk, and current prevention methods only partially offset this decline. A more effective, targeted prevention approach remains needed.
Citation ID: WS00554
Title: We can't yet fully prevent the bone density loss that occurs after menopause.
URL: https://www.worldsolve.org/index.php?api=problem&id=554
We don't have an effective way to treat chronic dry eye syndrome for a significant share of sufferers.
open
Global / Unspecified, Global
Chronic dry eye can be persistent and uncomfortable, and while treatments exist, many patients don't find lasting relief from current options. A more effective, longer-lasting treatment remains an unmet need.
Citation ID: WS00553
Title: We don't have an effective way to treat chronic dry eye syndrome for a significant share of sufferers.
URL: https://www.worldsolve.org/index.php?api=problem&id=553
We haven't solved how to prevent malnutrition-related stunting in children in food-insecure regions.
open
Global / Unspecified, Global
Chronic malnutrition in early childhood can cause lasting physical and cognitive effects that are difficult to reverse later in life. Preventing this before it happens remains far more effective, and far less solved, than treating it afterward.
Citation ID: WS00552
Title: We haven't solved how to prevent malnutrition-related stunting in children in food-insecure regions.
URL: https://www.worldsolve.org/index.php?api=problem&id=552
We can't yet fully explain why chronic inflammation persists in some people without an obvious ongoing cause.
open
Global / Unspecified, Global
Low-grade chronic inflammation is linked to numerous diseases, yet in many patients there's no clear infection or injury explaining why it continues. Understanding this could unlock treatments for a wide range of related conditions.
Citation ID: WS00551
Title: We can't yet fully explain why chronic inflammation persists in some people without an obvious ongoing cause.
URL: https://www.worldsolve.org/index.php?api=problem&id=551
We don't have a reliable, non-invasive way to diagnose endometriosis without surgery.
open
Global / Unspecified, Global
Confirming an endometriosis diagnosis often still requires invasive surgery, delaying treatment for patients who could benefit from earlier intervention. A reliable non-invasive diagnostic method remains an important unmet need.
Citation ID: WS00550
Title: We don't have a reliable, non-invasive way to diagnose endometriosis without surgery.
URL: https://www.worldsolve.org/index.php?api=problem&id=550
We haven't found a way to fully prevent the recurrence of ulcers in patients treated for H. pylori infection.
open
Global / Unspecified, Global
Even after successful treatment of the bacteria that commonly causes stomach ulcers, some patients experience recurring ulcers due to other contributing factors. A more comprehensive prevention approach remains needed.
Citation ID: WS00549
Title: We haven't found a way to fully prevent the recurrence of ulcers in patients treated for H. pylori infection.
URL: https://www.worldsolve.org/index.php?api=problem&id=549
We can't yet fully prevent the long-term cognitive effects of untreated sleep apnea.
open
Global / Unspecified, Global
Sleep apnea, when left untreated for years, is linked to cognitive decline and other health issues, yet many cases go undiagnosed simply because symptoms are mistaken for normal fatigue. Earlier, more widespread detection remains an unmet need.
Citation ID: WS00548
Title: We can't yet fully prevent the long-term cognitive effects of untreated sleep apnea.
URL: https://www.worldsolve.org/index.php?api=problem&id=548
We don't have an effective, affordable treatment for river blindness available everywhere it's needed.
open
Global / Unspecified, Global
This parasitic disease continues to cause preventable blindness in parts of Africa and Latin America, largely due to limited access to consistent treatment. Expanding affordable access remains the main barrier rather than lack of an effective treatment.
Citation ID: WS00547
Title: We don't have an effective, affordable treatment for river blindness available everywhere it's needed.
URL: https://www.worldsolve.org/index.php?api=problem&id=547
