What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We can't yet fully prevent the hearing damage caused by certain necessary medications.
open
Global / Unspecified, Global
Some life-saving medications, including certain antibiotics and chemotherapy drugs, carry a risk of permanent hearing damage as a side effect. A way to protect hearing during necessary treatment remains undeveloped.
Citation ID: WS00506
Title: We can't yet fully prevent the hearing damage caused by certain necessary medications.
URL: https://www.worldsolve.org/index.php?api=problem&id=506
We don't have a cure for most forms of infertility that don't respond to standard treatments.
open
Global / Unspecified, Global
Even with modern reproductive technology, a significant share of infertility cases have no clear cause and don't respond well to existing treatments. Understanding these unexplained cases remains a major gap in reproductive medicine.
Citation ID: WS00505
Title: We don't have a cure for most forms of infertility that don't respond to standard treatments.
URL: https://www.worldsolve.org/index.php?api=problem&id=505
We haven't solved how to make dialysis less physically and emotionally burdensome for long-term kidney patients.
open
Global / Unspecified, Global
Patients on dialysis often endure hours of treatment multiple times a week indefinitely, significantly affecting their quality of life. A better long-term solution, beyond transplant, remains an unmet need.
Citation ID: WS00504
Title: We haven't solved how to make dialysis less physically and emotionally burdensome for long-term kidney patients.
URL: https://www.worldsolve.org/index.php?api=problem&id=504
We can't yet reliably predict which patients will develop severe complications from diabetes years in advance.
open
Global / Unspecified, Global
Diabetes can lead to serious complications like blindness, kidney failure, or amputation, but predicting which patients are most at risk early enough to intervene remains imprecise. Better prediction could allow more targeted, effective prevention.
Citation ID: WS00503
Title: We can't yet reliably predict which patients will develop severe complications from diabetes years in advance.
URL: https://www.worldsolve.org/index.php?api=problem&id=503
We don't have an effective vaccine against most sexually transmitted infections beyond a few specific viruses.
open
Global / Unspecified, Global
Effective vaccines exist for a small number of sexually transmitted infections, but many common ones still have no vaccine available at all. Expanding vaccine coverage here could significantly reduce global disease burden.
Citation ID: WS00502
Title: We don't have an effective vaccine against most sexually transmitted infections beyond a few specific viruses.
URL: https://www.worldsolve.org/index.php?api=problem&id=502
We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment.
open
Global / Unspecified, Global
This gut infection frequently returns after treatment, partly because antibiotics disrupt the broader gut microbiome that would normally help prevent it. Better prevention of recurrence remains an unresolved clinical challenge.
Citation ID: WS00501
Title: We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment.
URL: https://www.worldsolve.org/index.php?api=problem&id=501
We can't yet cure celiac disease, only manage it through strict dietary avoidance.
open
Global / Unspecified, Global
People with celiac disease must avoid gluten completely for life, since no treatment currently exists to let them safely consume it again. A real treatment or cure would free patients from this lifelong dietary restriction.
Citation ID: WS00500
Title: We can't yet cure celiac disease, only manage it through strict dietary avoidance.
URL: https://www.worldsolve.org/index.php?api=problem&id=500
We don't have a reliable way to reverse the cognitive decline caused by traumatic brain injury.
open
Global / Unspecified, Global
Even mild traumatic brain injuries can cause lasting cognitive effects that current treatments struggle to fully reverse. A better understanding of brain recovery mechanisms could open new treatment paths.
Citation ID: WS00499
Title: We don't have a reliable way to reverse the cognitive decline caused by traumatic brain injury.
URL: https://www.worldsolve.org/index.php?api=problem&id=499
We haven't solved why depression responds well to treatment in some patients but not others.
open
Global / Unspecified, Global
A significant share of patients with depression don't respond adequately to standard treatments, and doctors currently have limited ability to predict who will respond to which approach. Better personalized treatment matching remains an open challenge.
Citation ID: WS00498
Title: We haven't solved why depression responds well to treatment in some patients but not others.
URL: https://www.worldsolve.org/index.php?api=problem&id=498
We can't yet fully treat chronic lower back pain without relying heavily on management rather than resolution.
open
Global / Unspecified, Global
Lower back pain is one of the most common causes of disability worldwide, yet treatment for chronic cases still mostly focuses on symptom management rather than fixing underlying structural or nerve issues. A more definitive solution remains elusive.
Citation ID: WS00497
Title: We can't yet fully treat chronic lower back pain without relying heavily on management rather than resolution.
URL: https://www.worldsolve.org/index.php?api=problem&id=497
We don't have an effective way to prevent the progression of glaucoma before vision loss occurs.
open
Global / Unspecified, Global
Glaucoma often causes irreversible vision loss before it's diagnosed, since early stages typically have no noticeable symptoms. Better early detection and prevention methods remain a pressing unmet need in eye care.
Citation ID: WS00496
Title: We don't have an effective way to prevent the progression of glaucoma before vision loss occurs.
URL: https://www.worldsolve.org/index.php?api=problem&id=496
We haven't found a reliable cure for chronic sinusitis that works for the majority of sufferers.
open
Global / Unspecified, Global
Chronic sinus inflammation affects a large number of people and current treatments, from medication to surgery, often only partially resolve symptoms long-term. A more definitive treatment remains undeveloped.
Citation ID: WS00495
Title: We haven't found a reliable cure for chronic sinusitis that works for the majority of sufferers.
URL: https://www.worldsolve.org/index.php?api=problem&id=495
We can't yet fully prevent the long-term joint damage caused by rheumatoid arthritis.
open
Global / Unspecified, Global
Modern treatments can slow rheumatoid arthritis significantly, but many patients still experience some degree of joint damage over time despite treatment. Stopping this damage completely remains an unmet medical goal.
Citation ID: WS00494
Title: We can't yet fully prevent the long-term joint damage caused by rheumatoid arthritis.
URL: https://www.worldsolve.org/index.php?api=problem&id=494
We don't have a scalable, affordable treatment for hepatitis B available to everyone infected worldwide.
open
Global / Unspecified, Global
Effective treatments for hepatitis B exist, but cost and access remain out of reach for many of the hundreds of millions of people living with the infection globally, particularly in lower-income regions. Closing this access gap remains unresolved.
Citation ID: WS00493
Title: We don't have a scalable, affordable treatment for hepatitis B available to everyone infected worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=493
We haven't solved why some people develop severe complications from common infections that most people recover from easily.
open
Global / Unspecified, Global
The same virus or bacteria can cause mild illness in most people while triggering severe, sometimes life-threatening complications in others, and we still don't fully understand why. This gap makes predicting and preventing severe outcomes difficult.
Citation ID: WS00492
Title: We haven't solved why some people develop severe complications from common infections that most people recover from easily.
URL: https://www.worldsolve.org/index.php?api=problem&id=492
We can't yet cure multiple sclerosis, only slow its progression.
open
Global / Unspecified, Global
Current treatments for multiple sclerosis can reduce the frequency and severity of flare-ups but can't stop or reverse the underlying immune attack on the nervous system. A true cure remains an unmet goal after decades of research.
Citation ID: WS00491
Title: We can't yet cure multiple sclerosis, only slow its progression.
URL: https://www.worldsolve.org/index.php?api=problem&id=491
We don't have a reliable way to detect Parkinson's disease before physical symptoms like tremors appear.
open
Global / Unspecified, Global
By the time visible symptoms of Parkinson's appear, significant neurological damage has usually already occurred, limiting how much treatment can help. Detecting the disease years earlier could open the door to more effective intervention.
Citation ID: WS00490
Title: We don't have a reliable way to detect Parkinson's disease before physical symptoms like tremors appear.
URL: https://www.worldsolve.org/index.php?api=problem&id=490
We haven't found a way to prevent the muscle loss that comes with aging.
open
Global / Unspecified, Global
Age-related muscle loss, known as sarcopenia, contributes to frailty and falls in older adults, and current treatments rely mainly on exercise and diet rather than addressing the underlying biological decline. A more direct medical solution remains undeveloped.
Citation ID: WS00489
Title: We haven't found a way to prevent the muscle loss that comes with aging.
URL: https://www.worldsolve.org/index.php?api=problem&id=489
We can't yet fully treat eczema and other chronic skin conditions without ongoing management.
open
Global / Unspecified, Global
Chronic skin conditions often require lifelong management with creams and medications rather than a resolution of the underlying immune or genetic causes. A real cure, rather than continuous symptom control, remains unavailable.
Citation ID: WS00488
Title: We can't yet fully treat eczema and other chronic skin conditions without ongoing management.
URL: https://www.worldsolve.org/index.php?api=problem&id=488
We don't have an effective way to prevent hair loss caused by genetic or hormonal factors.
open
Global / Unspecified, Global
Existing treatments for hair loss can slow the process for some people but rarely reverse it completely, and the underlying biology of hair follicle loss isn't fully understood. A true prevention or reversal method remains undiscovered.
Citation ID: WS00487
Title: We don't have an effective way to prevent hair loss caused by genetic or hormonal factors.
URL: https://www.worldsolve.org/index.php?api=problem&id=487
