What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We don't have a reliable way to prevent the joint damage caused by gout attacks over time.
open
Global / Unspecified, Global
Repeated gout attacks can cause lasting joint damage even with treatment, and prevention still relies mainly on managing uric acid levels rather than fully eliminating the underlying risk. A more definitive prevention method remains unmet.
Citation ID: WS00526
Title: We don't have a reliable way to prevent the joint damage caused by gout attacks over time.
URL: https://www.worldsolve.org/index.php?api=problem&id=526
We haven't found a way to cure narcolepsy, only manage its symptoms with medication.
open
Global / Unspecified, Global
Narcolepsy causes sudden, uncontrollable sleep episodes that significantly disrupt daily life, and current treatments manage symptoms rather than address the underlying cause. A true cure remains undiscovered.
Citation ID: WS00525
Title: We haven't found a way to cure narcolepsy, only manage its symptoms with medication.
URL: https://www.worldsolve.org/index.php?api=problem&id=525
We can't yet reliably prevent the long-term lung damage caused by severe pneumonia.
open
Global / Unspecified, Global
Even after recovering from severe pneumonia, some patients experience lasting reductions in lung function that current treatments don't fully reverse. Preventing this lasting damage remains an unmet medical goal.
Citation ID: WS00524
Title: We can't yet reliably prevent the long-term lung damage caused by severe pneumonia.
URL: https://www.worldsolve.org/index.php?api=problem&id=524
We don't have an affordable cure for leishmaniasis available in all the regions where it's endemic.
open
Global / Unspecified, Global
This parasitic disease affects millions in tropical and subtropical regions, but effective treatment remains expensive, difficult to access, or logistically challenging for many affected communities. Closing this access gap remains unresolved.
Citation ID: WS00523
Title: We don't have an affordable cure for leishmaniasis available in all the regions where it's endemic.
URL: https://www.worldsolve.org/index.php?api=problem&id=523
We haven't solved how to treat postpartum psychosis quickly enough to prevent serious harm.
open
Global / Unspecified, Global
This rare but severe condition can develop rapidly after childbirth, and delays in recognition and treatment can have dangerous consequences for both mother and baby. Faster, more reliable detection and treatment protocols remain an urgent unmet need.
Citation ID: WS00522
Title: We haven't solved how to treat postpartum psychosis quickly enough to prevent serious harm.
URL: https://www.worldsolve.org/index.php?api=problem&id=522
We can't yet fully prevent the vision loss caused by diabetic retinopathy in all diabetic patients.
open
Global / Unspecified, Global
Diabetic retinopathy remains a leading cause of blindness among working-age adults, and while treatment can slow progression, prevention before damage begins remains incomplete. Earlier, more effective prevention could protect vision for millions of diabetics.
Citation ID: WS00521
Title: We can't yet fully prevent the vision loss caused by diabetic retinopathy in all diabetic patients.
URL: https://www.worldsolve.org/index.php?api=problem&id=521
We don't have a scalable solution for treating malnutrition in conflict zones where aid access is limited.
open
Global / Unspecified, Global
Malnutrition rates spike dramatically in areas affected by war, but delivering treatment consistently in unstable, hard-to-reach regions remains a persistent logistical and medical challenge. Solving this requires both medical and access innovation.
Citation ID: WS00520
Title: We don't have a scalable solution for treating malnutrition in conflict zones where aid access is limited.
URL: https://www.worldsolve.org/index.php?api=problem&id=520
We haven't found an effective way to treat most cases of chronic vertigo.
open
Global / Unspecified, Global
Persistent dizziness and balance problems can severely affect quality of life, yet treatment for many chronic cases remains limited and inconsistent. A more reliable, targeted treatment approach remains undeveloped.
Citation ID: WS00519
Title: We haven't found an effective way to treat most cases of chronic vertigo.
URL: https://www.worldsolve.org/index.php?api=problem&id=519
We can't yet fully understand why chronic stress leads to physical illness in some people more than others.
open
Global / Unspecified, Global
Chronic stress is linked to heart disease, digestive problems, and other physical illnesses, but why some people are more vulnerable to these effects than others isn't fully explained. Understanding this could improve both prevention and treatment.
Citation ID: WS00518
Title: We can't yet fully understand why chronic stress leads to physical illness in some people more than others.
URL: https://www.worldsolve.org/index.php?api=problem&id=518
We don't have a reliable way to prevent postoperative infections in a meaningful share of surgeries.
open
Global / Unspecified, Global
Even with strict sterile procedures, a portion of surgical patients still develop infections afterward, extending recovery and sometimes causing serious complications. Reducing this risk further remains an ongoing surgical challenge.
Citation ID: WS00517
Title: We don't have a reliable way to prevent postoperative infections in a meaningful share of surgeries.
URL: https://www.worldsolve.org/index.php?api=problem&id=517
We haven't solved why autoimmune diseases disproportionately affect women more than men.
open
Global / Unspecified, Global
The vast majority of autoimmune disease diagnoses occur in women, and the biological reasons behind this imbalance remain only partially understood. A clearer answer could open new treatment approaches for both sexes.
Citation ID: WS00516
Title: We haven't solved why autoimmune diseases disproportionately affect women more than men.
URL: https://www.worldsolve.org/index.php?api=problem&id=516
We can't yet fully prevent the nerve damage caused by long-term diabetes.
open
Global / Unspecified, Global
Diabetic neuropathy causes pain, numbness, and other complications that current treatments manage but don't reverse once nerve damage has occurred. Preventing this damage before it starts remains an important unmet goal.
Citation ID: WS00515
Title: We can't yet fully prevent the nerve damage caused by long-term diabetes.
URL: https://www.worldsolve.org/index.php?api=problem&id=515
We don't have an effective, widely available cure for chronic hepatitis C in every region where it's needed.
open
Global / Unspecified, Global
Highly effective hepatitis C treatments exist, but cost and healthcare access still prevent many infected people worldwide from receiving them. Expanding affordable access remains the primary barrier rather than the science itself.
Citation ID: WS00514
Title: We don't have an effective, widely available cure for chronic hepatitis C in every region where it's needed.
URL: https://www.worldsolve.org/index.php?api=problem&id=514
We haven't found a reliable way to detect early-stage Alzheimer's using a simple, affordable blood test.
open
Global / Unspecified, Global
Diagnosing Alzheimer's currently often requires expensive brain imaging or invasive procedures, limiting how widely early detection can be used. A cheap, accessible blood test could change how early treatment can begin.
Citation ID: WS00513
Title: We haven't found a reliable way to detect early-stage Alzheimer's using a simple, affordable blood test.
URL: https://www.worldsolve.org/index.php?api=problem&id=513
We can't yet cure chronic obstructive pulmonary disease, only slow its progression.
open
Global / Unspecified, Global
COPD gradually reduces lung function over years, and while treatment can ease symptoms and slow decline, it can't reverse the underlying lung damage. A cure remains out of reach for the millions living with this condition.
Citation ID: WS00512
Title: We can't yet cure chronic obstructive pulmonary disease, only slow its progression.
URL: https://www.worldsolve.org/index.php?api=problem&id=512
We don't have an effective way to reverse vision loss caused by macular degeneration in most cases.
open
Global / Unspecified, Global
Age-related macular degeneration is a leading cause of vision loss in older adults, and current treatments can slow progression in some cases but rarely restore lost vision. A true reversal treatment remains undeveloped.
Citation ID: WS00511
Title: We don't have an effective way to reverse vision loss caused by macular degeneration in most cases.
URL: https://www.worldsolve.org/index.php?api=problem&id=511
We haven't solved how to prevent the weight regain that follows most successful weight loss efforts.
open
Global / Unspecified, Global
Even when people successfully lose significant weight, the body's biology often works to regain it over time, undermining long-term success. Understanding and countering this biological pushback remains a major open challenge.
Citation ID: WS00510
Title: We haven't solved how to prevent the weight regain that follows most successful weight loss efforts.
URL: https://www.worldsolve.org/index.php?api=problem&id=510
We can't yet fully explain or treat chronic pelvic pain in a large share of affected patients.
open
Global / Unspecified, Global
Chronic pelvic pain often has no clearly identifiable cause even after extensive testing, leaving many patients with limited treatment options. A deeper understanding of its underlying causes remains needed.
Citation ID: WS00509
Title: We can't yet fully explain or treat chronic pelvic pain in a large share of affected patients.
URL: https://www.worldsolve.org/index.php?api=problem&id=509
We don't have a scalable way to screen for cervical cancer in regions without regular access to healthcare.
open
Global / Unspecified, Global
Cervical cancer remains highly preventable through regular screening, but many women in lower-resource regions lack consistent access to the tests that catch it early. Closing this access gap could prevent large numbers of otherwise preventable deaths.
Citation ID: WS00508
Title: We don't have a scalable way to screen for cervical cancer in regions without regular access to healthcare.
URL: https://www.worldsolve.org/index.php?api=problem&id=508
We haven't found a reliable way to treat chronic insomnia without long-term reliance on medication.
open
Global / Unspecified, Global
Many people with chronic insomnia end up relying on sleep medication for years, since non-drug treatments don't work consistently for everyone. A more effective, sustainable solution remains an open need.
Citation ID: WS00507
Title: We haven't found a reliable way to treat chronic insomnia without long-term reliance on medication.
URL: https://www.worldsolve.org/index.php?api=problem&id=507
